Spray works for skunks pretty effectively. Venomous snakes kill large grazing animals (horses, cattle, etc) if the grazer gets bit on the nose/muzzle, and the swelling blocks breathing. If Sasquatches exist, they must occasionally get sprayed by skunks and bitten by venomous snakes just like any other creature. Here in Alaska it's pretty accepted that spray works pretty well on nosy, curious bears, but will not work on pissed off bears. The problem is that we don't get to choose the bear's attitude when contact occurs. If I have the ability to carry a lot of gear, I bring a can of spray for my cook tent, but I carry a holstered firearm at all times, and I try to keep my rifle nearby...........like, within 10 yards.