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georgerm

Why can't we find and study Bigfoot?

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hiflier
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14 minutes ago, georgerm said:

How do we get past the DNA testing that always points to human contamination? We discussed markers that need to be looked at during a more exhaustive DNA analysis. The markers should point to another kind of primate other than humans

 

A very salient point! This is where it becomes time for the term "primers" to be explained. Primers are designed to target a certain species by zeroing in on a specific gene, or protein that a particular gene expresses. There are numerous primers already designed to detect certain organisms with new primers being added to the pile all the time. So getting past Human contamination is getting easier. Since Humans and Great Apes are so similar, especially when it comes to the Chimpanzee then it takes being able to target a gene or protein that is specific to either species.

 

There are primers for Chimp DNA detection, and there are primers for Human DNA detection. As far as we know, there is NO Sasquatch DNA (in the GenBank!) so how does one create a primer to detect the creature's DNA? After everything I've presented on this Forum as the solution maybe you or someone would now be able to answer that question? I'll give you a hint: One doesn't HAVE to create a new primer for Sasquatch detection.

 

This goes as a direct answer to the question you composed as the title for this thread :)  

Edited by hiflier

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Huntster
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1 hour ago, SWWASAS said:

.......Should bigfoot be accepted like the mountain gorilla is, then the pool of expert speakers would rapidly dry up to those few who actually get in the field, like Fossey did,  establish contact  and find out something about the species.   .     Most of what is presented now is conjecture.     That they exist,  what they are, their origins,  their relationship to man,   all are conjectore that anyone can engage in,   speak at conferences,  write books,  tell stories,  have blogs, and most importantly people are making money from many aspects.     Most of that goes away with acceptance by science..........

 

It doesn't go away. It just changes who makes the money, and how. You pointed that out very well. And, really, some of that (without the money making in carnival style) might have already occurred, or even is still occurring.

 

.......While your crusade for discovery is applaudable,   I am not sure that discovery would benefit bigfoot.    It will likely happen at some point anyway.  Might as well be you as anyone else,    The species would become mired in government red tape.  

People like me, likely restricted from attempting contact,  and large chunks of woods become a forest preserve........

 

That government might use the species as an excuse to justify tyrannical land use policies is a common fear among many, and I'm absolutely positive that government would codify or administratively declare some lands as some sort of sasquatch preserve, but they can't easily prevent people from accessing said lands on foot. They can restrict vehicular access, but walking in is almost guaranteed. It's difficult for them to ban all access. Military lands (due to the dangers of unexploded ordnance) or some watershed areas (due to pollution fears) are off limits. But even then, sneaking in on foot is easy, and criminal penalties for doing so are almost non-existent.

 

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georgerm
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2 hours ago, hiflier said:

 

A very salient point! This is where it becomes time for the term "primers" to be explained. Primers are designed to target a certain species by zeroing in on a specific gene, or protein that a particular gene expresses. There are numerous primers already designed to detect certain organisms with new primers being added to the pile all the time. So getting past Human contamination is getting easier. Since Humans and Great Apes are so similar, especially when it comes to the Chimpanzee then it takes being able to target a gene or protein that is specific to either species.

 

There are primers for Chimp DNA detection, and there are primers for Human DNA detection. As far as we know, there is NO Sasquatch DNA (in the GenBank!) so how does one create a primer to detect the creature's DNA? After everything I've presented on this Forum as the solution maybe you or someone would now be able to answer that question? I'll give you a hint: One doesn't HAVE to create a new primer for Sasquatch detection.

 

This goes as a direct answer to the question you composed as the title for this thread :)  

 

If a creek drainage coming off a mountain is tested for e-DNA, and one test shows primers for a human. We know a human lives in a cabin high on the hill. Then another e-DNA test shows different primers for another species of primate living up on the mountain then it's bigfoot or an escaped monkey! 

 

 

Edited by georgerm

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hiflier
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In a sense yes. Primers are what one uses to seek out the DNA elements one is targeting. Primers are not the results, they are only a means used to zero in on a selected gene, or the gene-expressed protein, one is looking for. The trick to the whole thing is KNOWING which gene or expressed gene protein is specific to which organism. Science knows that NOTCH2NL's that don't express proteins belong ONLY to Gorillas and Chimpanzees, Bonobos, and Bili Apes. And Science knows that NOTCH2NLA, B, and C do express proteins and only belong to Humans. All we need are the primers that will identify one group of genes or the other.

 

Basically if one is using an e-DNA primer that detects say, the Human NOTCH2NLB, but the gene isn't present in a supposed Human DNA contaminated sample then the sample isn't Human contaminated. Because if it's missing the specific Human "B" variation one was looking for? Then it's a primate yes, but not Human primate. The cool thing here is that everything one needs to do this kind of environmental sampling already exists. It will only take someone implementing the idea in the field to see what's really out there, and where.  

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