There are many documented incidents of people shooting at a Sasquatch and, in some instances, actually killing them. However, they are all testimonial in nature and none, to my knowledge, resulted in any physical evidence. I'm not including the Sierra Kills as the results, from MK, have not been published.
The bottom line is, we don't have a tremendous amount of physical or photographic evidence but we do have a tremendous amount of anecdotal evidence.
This is the "rub," so to speak. A skeptic will present many logical reason as to why Bigfoot does not exist and it's hard to counter that because they are right.
However, the flip side is also true, in that we can present a tremendous amount of anecdotal evidence, from very credible sources, and it's very hard to counter the sheer volume, detail and credibility of the sightings and/ or the person telling it. Some can be weeded out, but not all and there a lot of sightings that can't be easily dismissed.
So, until a body is found, or all of the sightings can be discredited, we're in a no win situation.