Even though there is no reference sequence for Bigfoot, eDNA may still yield a sequence with no exact match to any known primate or a close human relationship. Comparing that DNA to known primates would place it in the phylotree. eDNA is used all the time to validate new species claims and position the new species in the phylotree. However, other evidence, specimens, photographs, or videos are also usually required to gain acceptance for a new species. Note the case of the lesula monkey as an example: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044271
Here, however, the DNA was taken directly from a specimen.