If it is classified as in the genus Homo, it would be *human*, so killing one would be *homicide*. But remember, more primitive bipedal apes (Australopithecus, Ardipithecus, Sahelanthropus, Oreopithecus, Danuvius, etc) lived at least several millions of years ago. The earliest homo species was 2.5 million years ago.
It is definitely homicide, but not necessarily murder. Murder is defined as an illegal and intentional homicide. Self defense is a legal justification for homicide.
But if a sasquatch decides to kill a man? It is almost certainly not possible to legally prosecute the sasquatch for murder if he is also a wild animal.